Nice to meet you
My work spans from first-in-human testing of novel therapeutics to their application in patients with complex diseases. As an internationally recognized leader in polypharmacy, drug safety, and medicines optimization, I am dedicated to delivering better and safer medications for individuals living with multimorbidity.
My clinical expertise extends to leading outpatient clinics, inpatient reviews, and multidisciplinary team meetings for adults with complex multimorbidity and polypharmacy.
Passionate about advancing healthcare through research and collaboration, I am committed to optimizing medication use and improving patient outcomes on a national and international scale.


Education & Training Offerings
Polypharmacy & Multimorbidity Management
Understanding drug interactions and disease progression in complex patients.
Medicines Optimization & Deprescribing
Identifying when medication harms outweigh benefits.
AI & Machine Learning in Clinical Decision-Making
Exploring how AI-driven insights enhance prescribing and risk prediction.
Experimental Therapeutics & Drug Development
Understanding early-phase clinical trials and novel therapies.








Research & Innovations
AI-driven prescribing optimization
Identifying disease and prescribing trajectories in people with complex care needs. Visit
Health record analytics
Using machine learning to predict risks and improve patient safety.
Clinical decision support tools
Developing tools for optimizing HIV prescribing and multimorbidity care.








Clinical & Leadership Roles
Deputy Director, NIHR Clinical Research Facility
Supporting early-phase clinical trials and precision medicine research.
Professor of Clinical Pharmacology & Therapeutics
Managing complex multimorbidity cases, inpatient reviews, and multidisciplinary team meetings.
Senior Investigator, AGILE Trial
Co-leading UK’s only government-funded early-phase COVID-19 therapeutic trial. Visit
Co-Director -TherEx
Innovating therapies for complex diseases with a particular focus on infection therapeutics


Chief Investigator
High-Dose Nitazoxanide Repurposing for COVID-19 – Ensuring low-cost global solutions through Unitaid-funded research.
Co-Chair
INational Polypharmacy Services Consortium (PPSC) – Developing an integrated, multidisciplinary approach to polypharmacy management.










Co-Director of NIHR
Cheshire & Mersey Commercial Research Delivery Centre
DynAIRx
DynAIRx (Artificial Intelligence for dynamic prescribing optimisation and care integration in multimorbidity) aims to develop new, easy to use, artificial intelligence (AI) tools that support General Practitioners (GPs) and pharmacists to find patients living with multimorbidity (two or more long-term health conditions) who might be offered a better combination of medicines.


Key Publications & Academic Contributions


Walker LE, et al. AI for dynamic prescribing optimization and care integration in multimorbidity. J Multimorb Comorb, 2022.
Kuan V, Denaxas S, Walker LE, et al. Identifying and visualizing multimorbidity patterns in NHS patients. Lancet Digital Health, 2023.
Abuzour AS, Walker LE, et al. Barriers to structured medication reviews in primary care: The DynAIRx Study. PLoS ONE, 2024.
Braithwaite E, Todd OM, Walker LE, et al. Interventions for reducing anticholinergic medication burden in older adults. Age and Ageing, 2023.
Walker LE, Fitzgerald R, et al. An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers: A COVID-19 Antiviral Candidate. Clin Pharmacol Ther, 2022.








Trying my best to learn
University of Liverpool
Post-Graduate Certificate Academic Practice (PGCAP)
2020
University of Liverpool
PhD Pharmacology
2015
University of Liverpool
M.B., Ch. B (Hons)
2007
Education
Membership
Sponsorship Committee
Member
2023
Cure C ethics committee
Member
2022
Athena Swan Committee
Member
2023


Have any questions?
If you have any questions about the therapies, feel free to contact us.